A Cell Culture (Vero)–Derived H5N1 Whole-Virus Vaccine Induces Cross-Reactive Memory Responses
Identifieur interne : 001A39 ( Istex/Curation ); précédent : 001A38; suivant : 001A40A Cell Culture (Vero)–Derived H5N1 Whole-Virus Vaccine Induces Cross-Reactive Memory Responses
Auteurs : Hartmut J. Ehrlich ; Markus Müller [Autriche] ; Sandor Fritsch ; Markus Zeitlinger [Autriche] ; Greg Berezuk ; Alexandra Löw-Baselli ; Maikel V. W. Van Der Velden ; Eva Maria Pöllabauer ; Friedrich Maritsch ; Borislava G. Pavlova ; Paul A. Tambyah ; Helen M. L. Oh [Singapour] ; Emanuele Montomoli [Italie] ; Otfried Kistner ; P. Noel BarrettSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2009.
Abstract
Novel strategies are required to provide rapid vaccine coverage in the event of an influenza pandemic. A phase I/II dose finding/formulation study was performed with a whole-virus H5N1 clade 1 A/Vietnam vaccine (2-dose priming regimen) to evaluate safety and immunogenicity. Seventy-seven of 141 subjects in this study received a booster (12–17 months after priming) with a 7.5-μg dose of a clade 2.1 A/Indonesia vaccine. The prime-boost regimen resulted in antibody responses against clade 1, 2.1, 2.2, and 2.3 viruses that were significantly higher than those after the priming regimen. These findings demonstrate that a prime-boost regimen may alleviate vaccine supply constraints in a pandemic Clinical trials registrationNCT00530660
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DOI: 10.1086/605608
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Hartmut J. Ehrlich<affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>National University of Singapore and</mods:affiliation><wicri:noCountry code="no comma">National University of Singapore and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation>Le document en format XML
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Ehrlich</name><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Muller, Markus" sort="Muller, Markus" uniqKey="Muller M" first="Markus" last="Müller">Markus Müller</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Pharmacology, Medical University Vienna, Vienna General Hospital, Vienna, Austria;</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Autriche</country><wicri:regionArea>Department of Clinical Pharmacology, Medical University Vienna, Vienna General Hospital, Vienna</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: markus.mueller@meduniwien.ac.at</mods:affiliation><country wicri:rule="url">Autriche</country></affiliation></author><author><name sortKey="Fritsch, Sandor" sort="Fritsch, Sandor" uniqKey="Fritsch S" first="Sandor" last="Fritsch">Sandor Fritsch</name><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Zeitlinger, Markus" sort="Zeitlinger, Markus" uniqKey="Zeitlinger M" first="Markus" last="Zeitlinger">Markus Zeitlinger</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Pharmacology, Medical University Vienna, Vienna General Hospital, Vienna, Austria;</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Autriche</country><wicri:regionArea>Department of Clinical Pharmacology, Medical University Vienna, Vienna General Hospital, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Berezuk, Greg" sort="Berezuk, Greg" uniqKey="Berezuk G" first="Greg" last="Berezuk">Greg Berezuk</name><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Low Baselli, Alexandra" sort="Low Baselli, Alexandra" uniqKey="Low Baselli A" first="Alexandra" last="Löw-Baselli">Alexandra Löw-Baselli</name><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Van Der Velden, Maikel V W" sort="Van Der Velden, Maikel V W" uniqKey="Van Der Velden M" first="Maikel V. W." last="Van Der Velden">Maikel V. W. Van Der Velden</name><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Pollabauer, Eva Maria" sort="Pollabauer, Eva Maria" uniqKey="Pollabauer E" first="Eva Maria" last="Pöllabauer">Eva Maria Pöllabauer</name><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Maritsch, Friedrich" sort="Maritsch, Friedrich" uniqKey="Maritsch F" first="Friedrich" last="Maritsch">Friedrich Maritsch</name><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Pavlova, Borislava G" sort="Pavlova, Borislava G" uniqKey="Pavlova B" first="Borislava G." last="Pavlova">Borislava G. Pavlova</name><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Tambyah, Paul A" sort="Tambyah, Paul A" uniqKey="Tambyah P" first="Paul A." last="Tambyah">Paul A. Tambyah</name><affiliation><mods:affiliation>National University of Singapore and</mods:affiliation><wicri:noCountry code="no comma">National University of Singapore and</wicri:noCountry></affiliation></author><author><name sortKey="Oh, Helen M L" sort="Oh, Helen M L" uniqKey="Oh H" first="Helen M. L." last="Oh">Helen M. L. Oh</name><affiliation wicri:level="1"><mods:affiliation>Changi General Hospital, Singapore; and</mods:affiliation><country xml:lang="fr" wicri:curation="lc">Singapour</country><wicri:regionArea>Changi General Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Montomoli, Emanuele" sort="Montomoli, Emanuele" uniqKey="Montomoli E" first="Emanuele" last="Montomoli">Emanuele Montomoli</name><affiliation wicri:level="1"><mods:affiliation>University of Siena, Siena, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Siena, Siena</wicri:regionArea></affiliation></author><author><name sortKey="Kistner, Otfried" sort="Kistner, Otfried" uniqKey="Kistner O" first="Otfried" last="Kistner">Otfried Kistner</name><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Noel Barrett, P" sort="Noel Barrett, P" uniqKey="Noel Barrett P" first="P." last="Noel Barrett">P. Noel Barrett</name><affiliation><mods:affiliation>Global R&D, Baxter BioScience, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2009</date><biblScope unit="vol">200</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1113">1113</biblScope><biblScope unit="page" to="1118">1118</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Novel strategies are required to provide rapid vaccine coverage in the event of an influenza pandemic. A phase I/II dose finding/formulation study was performed with a whole-virus H5N1 clade 1 A/Vietnam vaccine (2-dose priming regimen) to evaluate safety and immunogenicity. Seventy-seven of 141 subjects in this study received a booster (12–17 months after priming) with a 7.5-μg dose of a clade 2.1 A/Indonesia vaccine. The prime-boost regimen resulted in antibody responses against clade 1, 2.1, 2.2, and 2.3 viruses that were significantly higher than those after the priming regimen. These findings demonstrate that a prime-boost regimen may alleviate vaccine supply constraints in a pandemic Clinical trials registrationNCT00530660</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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